Growth-associated protein (GAP-43) in terminal Schwann cells of rat Pacinian corpuscles
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Axons physiology MeSH
- Rats MeSH
- Membrane Glycoproteins biosynthesis MeSH
- Sciatic Nerve physiology MeSH
- Animals, Newborn MeSH
- Rats, Sprague-Dawley MeSH
- GAP-43 Protein MeSH
- Nerve Tissue Proteins biosynthesis MeSH
- Nerve Regeneration MeSH
- Nerve Crush MeSH
- Growth Substances biosynthesis MeSH
- Schwann Cells physiology MeSH
- Aging MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Membrane Glycoproteins MeSH
- GAP-43 Protein MeSH
- Nerve Tissue Proteins MeSH
- Growth Substances MeSH
Growth-associated protein (GAP-43) immunoreactivity was examined in Pacinian corpuscles of intact neonatal and adult rats as well as after denervation and reinnervation in adult rats. All immature Pacinian corpuscles were GAP-43 immunoreactive (GAP-43+) in their inner cores while only 46 +/- 5.6% of the mature corpuscles exhibited GAP-43+ inner cores. The frequency of GAP-43+ inner cores increased to 90 +/- 7.2% after their permanent denervation. The expression of GAP-43 in the inner cores was reduced by contact with regrowing axons, but 38 +/- 5.3% of Pacinian corpuscles retained GAP-43+ in their inner cores following reinnervation. These results indicate that GAP-43 regulation is not confined only to axons but also involves some extra-axonal cues, and support a role for this protein in the process formation by terminal Schwann cells.
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