Essential fatty acid deficiency and bone fragility in rats
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
8997644
Knihovny.cz E-resources
- MeSH
- Dietary Fats pharmacology MeSH
- Ergocalciferols pharmacology MeSH
- Femoral Fractures pathology MeSH
- Tibial Fractures pathology MeSH
- Rats MeSH
- Fatty Acids pharmacology MeSH
- Rats, Wistar MeSH
- Bone Diseases, Developmental pathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Dietary Fats MeSH
- Ergocalciferols MeSH
- Fatty Acids MeSH
This study demonstrates the effect of essential fatty acid deficiency on the postnatal skeletal development in the rat. Four groups (n = 10) of newborn Wistar rats were fed diets containing high and low proportions of essential fatty acids in the lipid fraction until day 16 after birth. Suckled littermates were used as controls. X-ray and histological studies showed the occurrence of multiple pathological fractures of the long bones in 1-month-old rats fed a diet deprived of essential fatty acids. No effect of high (51,000 IU/100 g diet) and low (5,100 IU/100 g diet) concentrations of vitamin D2 was observed in our experiment. Thus, these data suggest the importance of essential fatty acids for bone pathology in the rat.
