Radioprotective properties of flurbiprofen
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
8997646
Knihovny.cz E-resources
- MeSH
- Prostaglandin Antagonists administration & dosage MeSH
- Flurbiprofen administration & dosage MeSH
- Granulocytes drug effects radiation effects MeSH
- Lymphocytes drug effects radiation effects MeSH
- Mice, Inbred C57BL MeSH
- Mice, Inbred CBA MeSH
- Mice MeSH
- Spleen drug effects radiation effects MeSH
- Gamma Rays * MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Prostaglandin Antagonists MeSH
- Flurbiprofen MeSH
Repeated administration of flurbiprofen, an inhibitor of prostaglandin synthesis (IPS), was found to enhance haemopoiesis in mice exposed to a sublethal dose of fractionated gamma-irradiation (5 x 3 Gy, intervals between fractions 24 h). In lethally irradiated animals (5 x 3 Gy and an additional "top-up" dose of 3.5 Gy), a significantly better survival was found in mice given flurbiprofen than in control animals receiving saline. The latter result is a new positive phenomenon not observed in earlier experiments with other IPS. The findings suggest a possibility to extend the radiation dose range, in which the administration of IPS leads to radioprotective effects, also to higher, lethal radiation doses, by administering flurbiprofen instead of previously studied IPS indomethacin or diclofenac.
Stimulatory action of cyclooxygenase inhibitors on hematopoiesis: a review
