Poly (triethylenglycol monomethacrylate) and poly (glycerol monomethacrylate) cross-linked gel as potential viscoelastics for intraoperative use
Jazyk angličtina Země Německo Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
9085115
DOI
10.1007/bf00941727
Knihovny.cz E-zdroje
- MeSH
- biokompatibilní materiály MeSH
- gely MeSH
- králíci MeSH
- kyseliny polymethakrylové terapeutické užití MeSH
- oči účinky léků patologie MeSH
- přední segment oční chirurgie MeSH
- protézy a implantáty * MeSH
- pružnost MeSH
- rohovka účinky léků patologie MeSH
- rohovkový endotel účinky léků patologie MeSH
- viskozita MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biokompatibilní materiály MeSH
- gely MeSH
- kyseliny polymethakrylové MeSH
BACKGROUND: The highly swelling poly (glycerol monomethacrylate) gel (polyGLYMA) and hydrophilic polymer poly (triethylenglycol monomethacrylate (polyTEGMA) were tested as potential viscoelastics for intraoperative use in anterior segment surgery. METHODS: PolyGLYMA was implanted into the anterior chamber in 5 rabbits, and 40% polyTEGMA in 16 rabbits. The eyes were enucleated 1 week to 3 months after the operation. The corneal endothelium was examined with specular microscopy, and then the whole eye histopathologically. RESULTS: In all eyes of the polyGLYMA group, the clinical findings were characterized by a marked ciliary injection and severe secondary glaucoma, and the histologic ones by a marked inflammatory infiltration and thickening of Descemet's membrane in the anterior chamber angle. Specular microscopy revealed a decrease in the endothelial cell density and polymorphism of the endothelial cells. In the polyTEGMA group, the anterior segment and the fundus were physiologic all the time, and specular microscopy and histologic findings showed no degenerative and/or inflammatory changes. CONCLUSIONS: PolyGLYMA proved unsuitable for intracameral application in rabbits. The new polymer polyTEGMA is characterized by high biologic tolerance after its implantation into the anterior chamber of rabbits. PolyTEGMA 40% might be considered as a potential viscoelastic material in humans.
Zobrazit více v PubMed
J Biomed Mater Res. 1971 Jan;5(1):113-9 PubMed
Cesk Oftalmol. 1982 Jan;38(1):27-32 PubMed
J Cataract Refract Surg. 1990 Sep;16(5):567-77 PubMed
Arch Ophthalmol. 1968 Jul;80(1):120-7 PubMed
Cesk Oftalmol. 1992 Jul;48(4):241-6 PubMed
Mod Probl Ophthalmol. 1974;12(0):385-9 PubMed
