Respiratory control index of mitochondria isolated from regenerating rat liver
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
9200218
Knihovny.cz E-resources
- MeSH
- Hepatectomy MeSH
- Mitochondria, Liver metabolism MeSH
- Rats MeSH
- Succinic Acid MeSH
- Fatty Acids, Nonesterified metabolism MeSH
- Oxidative Phosphorylation MeSH
- Rats, Wistar MeSH
- Liver Regeneration * MeSH
- Serum Albumin, Bovine pharmacology MeSH
- Oxygen Consumption * MeSH
- Succinates metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Succinic Acid MeSH
- Fatty Acids, Nonesterified MeSH
- Serum Albumin, Bovine MeSH
- Succinates MeSH
Mitochondria were isolated from regenerating rat liver 12, 24 and 48 h after partial hepatectomy. The "State 3" and "State 4" respiration were measured in the presence of succinate. The P/O quotient and respiratory control index (RCI) were calculated. The experimental data showed that the partial uncoupling of oxidative phosphorylation in regenerating liver mitochondria occurring in the early period of regeneration is partly due to free fatty acids.
