Liver cell cytoplasmic inclusions in experimental porphyrias: their demonstration with the ferric ferricyanide reduction reaction
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
9314066
DOI
10.1016/s0940-2993(97)80038-3
PII: S0940-2993(97)80038-3
Knihovny.cz E-resources
- MeSH
- Benzamides MeSH
- Inclusion Bodies ultrastructure MeSH
- Ferricyanides chemistry MeSH
- Herbicides MeSH
- Hexachlorobenzene MeSH
- Liver ultrastructure MeSH
- Rats MeSH
- Humans MeSH
- Disease Models, Animal * MeSH
- Mice MeSH
- Oxidation-Reduction MeSH
- Polychlorinated Biphenyls MeSH
- Porphyrias chemically induced pathology MeSH
- Porphyria Cutanea Tarda pathology MeSH
- Rats, Wistar MeSH
- Fungicides, Industrial MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 2,4',5-trichlorobiphenyl MeSH Browser
- Benzamides MeSH
- ferric ferricyanide MeSH Browser
- Ferricyanides MeSH
- fomesafen MeSH Browser
- Herbicides MeSH
- Hexachlorobenzene MeSH
- Polychlorinated Biphenyls MeSH
- Fungicides, Industrial MeSH
In the present paper we describe needle-shaped and granular cytoplasmic inclusions in the liver cells of mice and rats with experimental porphyria biochemically resembling human porphyria cutanea tarda. The inclusions were inconspicuous in routine histological slides. The ferric ferricyanide reduction reaction, however, enabled us to demonstrate their shape and location within the hepatic lobule. Needle-shaped inclusions are considered to represent a structure specifically seen in experimental porphyrias resembling porphyria cutanea tarda. These structures are similar to the inclusions seen in human porphyria cutanea tarda.
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