Blood pressure and renal function in autosomal dominant polycystic kidney disease
Language English Country Germany Media print
Document type Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
PubMed
9323285
DOI
10.1007/s004670050343
Knihovny.cz E-resources
- MeSH
- Blood Pressure Monitoring, Ambulatory MeSH
- Child MeSH
- Adult MeSH
- Glomerular Filtration Rate physiology MeSH
- Blood Pressure physiology MeSH
- Kidney diagnostic imaging physiopathology MeSH
- Humans MeSH
- Adolescent MeSH
- Polycystic Kidney, Autosomal Dominant diagnostic imaging physiopathology MeSH
- Ultrasonography MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
The purpose of this study was to identify hypertension in children and adolescents in an early stage of autosomal dominant polycystic kidney disease (ADPKD) by the application of ambulatory blood pressure monitoring (ABPM) over 24 h; 32 children and adolescents (mean age 12.3 +/- 4.7 years) were examined. The diagnosis was based on family history and ultrasound examination. In 21 children ADPKD was confirmed by molecular genetic analysis. At the time of the study, 45% patients were asymptomatic and all had glomerular filtration rates (GFRs) > or = 65 ml/min per 1.73 m2. By ABPM, 11 patients (34%) were defined as hypertensive (systolic or diastolic blood pressure > 95th percentile), including 4 with an exclusive nocturnal hypertension. Of 7 patients with daytime hypertension, 4 had normal blood pressure by casual measurements. The nocturnal dip in blood pressure was reduced in 2 patients. Blood pressure correlated with renal size, but not with GFR, concentrating capacity, proteinuria, and plasma renin activity. The study reveals an early trend for increased blood pressure in children with ADPKD, requiring close supervision.
References provided by Crossref.org
Genotype-phenotype correlation in children with autosomal dominant polycystic kidney disease
