Melatonin entrainment of the circadian N-acetyltransferase rhythm in the newborn rat pineal gland
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Antioxidants administration & dosage pharmacology MeSH
- Arylamine N-Acetyltransferase metabolism MeSH
- Circadian Rhythm drug effects MeSH
- Pineal Gland enzymology MeSH
- Injections, Subcutaneous MeSH
- Rats MeSH
- Melatonin administration & dosage pharmacology MeSH
- Animals, Newborn MeSH
- Rats, Wistar MeSH
- Pregnancy MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antioxidants MeSH
- Arylamine N-Acetyltransferase MeSH
- Melatonin MeSH
In 15-day-old control and vehicle-treated rats, the evening rise of the pineal N-acetyltransferase occurred at the same time as in their mothers, whereas in 5-day-old pups, the rise occurred by 2-3 hr earlier. Four-day administration of melatonin in the late day phase advanced the N-acetyltransferase rise in 15-day-old rats as compared with the rise in the vehicle-treated animals; a slight melatonin induced phase advance in 5- and 27-day-old rats was not significant. The data indicate that the newborn rat's circadian pacemaker controlling the rhythmic N-acetyltransferase rise may be entrained by exogenous melatonin. It appears, however, that the maternal melatonin transferred via milk cannot entrain the pup's pacemaker by phase advancing it, since the N-acetyltransferase rise in the pups begins earlier or at the same time as maternal melatonin production driven by the N-acetyltransferase rhythm.
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