Postantibiotic effects and postantibiotic sub-MIC effects of ciprofloxacin, pefloxacin and amikacin on the biological properties of Salmonella strains
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
9449780
DOI
10.1007/bf02816944
Knihovny.cz E-resources
- MeSH
- Virus Activation drug effects MeSH
- Amikacin administration & dosage pharmacology MeSH
- Anti-Bacterial Agents administration & dosage pharmacology MeSH
- Anti-Infective Agents administration & dosage pharmacology MeSH
- Bacteriophages MeSH
- Coloring Agents MeSH
- Cell Wall chemistry drug effects MeSH
- Chemical Phenomena MeSH
- Ciprofloxacin administration & dosage pharmacology MeSH
- Salmonella Phages drug effects growth & development MeSH
- Chemistry, Physical MeSH
- Congo Red MeSH
- Microbial Sensitivity Tests MeSH
- Pefloxacin administration & dosage pharmacology MeSH
- Salmonella enteritidis drug effects metabolism MeSH
- Salmonella typhimurium drug effects metabolism virology MeSH
- Dose-Response Relationship, Drug MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Amikacin MeSH
- Anti-Bacterial Agents MeSH
- Anti-Infective Agents MeSH
- Coloring Agents MeSH
- Ciprofloxacin MeSH
- Congo Red MeSH
- Pefloxacin MeSH
The postantibiotic effect (PAE) and the postantibiotic sub-MIC effect (PASME) of ciprofloxacin, pefloxacin and amikacin were studied for Salmonella typhimurium and S. enteritidis strains. PAE was induced by 2 x and 4 x MIC of antibiotics studied for 0.5 h. After PAE and PASME their effect on prophage induction of a lysogenic S. typhimurium strain and on Congo red binding for both strains as a marker of their surface hydrophobicity was examined. The longest PAE was found after treatment with ciprofloxacin, higher values being observed with S. typhimurium. PAEs of pefloxacin and amikacin were much lower, except for the suprainhibitory concentration 4 x MIC of amikacin with S. enteritidis (6.9h). PASMEs of ciprofloxacin did not allow any regrowth of either strain. For other antibiotics the PASMEs were different while concentrations of 2 x MIC + 0.2 x MIC and 0.3 x MIC, and of 4 x MIC + 0.1 x MIC, 0.2 x MIC and 0.3 x MIC of amikacin did not allow any regrowth of S. enteritidis. PAEs of the antibiotics tested did not affect the Congo red binding by both Salmonella strains, but the PAEs of ciprofloxacin and pefloxacin expressively induced a prophage of lysogenic S. typhimurium strain. We noted the influence of Congo red binding after applying 4 x MIC + 0.1 x MIC, 0.2 x MIC and 0.3 x MIC of amikacin for S. typhimurium and 2 x MIC + 0.1 x MIC for S. enteritidis.
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