Mutational changes in the hemagglutinin of equine H3 influenza viruses result in the introduction of a glycosylation site which enhances the infectivity of the viruses
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
9449785
DOI
10.1007/bf02816955
Knihovny.cz E-zdroje
- MeSH
- asparagin chemie MeSH
- cytopatogenní efekt virový MeSH
- glykosylace účinky léků MeSH
- hemaglutininové glykoproteiny viru chřipky chemie genetika fyziologie MeSH
- konsenzuální sekvence MeSH
- kultivované buňky MeSH
- kuřecí embryo MeSH
- molekulární sekvence - údaje MeSH
- posttranslační úpravy proteinů * účinky léků MeSH
- sekvence aminokyselin MeSH
- sekvenční homologie aminokyselin MeSH
- sekvenční seřazení MeSH
- tunikamycin farmakologie MeSH
- virulence genetika MeSH
- virus chřipky A genetika patogenita MeSH
- zvířata MeSH
- Check Tag
- kuřecí embryo MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Geografické názvy
- Nigérie MeSH
- Názvy látek
- asparagin MeSH
- hemaglutininové glykoproteiny viru chřipky MeSH
- tunikamycin MeSH
The complete amino acid sequences of the hemagglutinin (HA) glycoprotein of three equine-2 influenza viruses from tropical Africa are presented in comparison with that of a well characterized European equine-2 virus (Suffolk/89) and a consensus sequence from the database. The sequences of the tropical African viruses were deduced from the complete nucleotide sequences of their HA genes reported earlier. Mutational changes in the nucleotide sequences resulted in amino acid changes in the HA which led to the introduction of a new asparagine-linked (N-linked) glycosylation site in two viruses. This new glycosylation site enhanced the infectivity of these viruses as investigated by plaque assay, virus titration in embryonated chicken eggs and tunicamycin treatment. The role of N-linked glycosylation of influenza virus HA glycoprotein in virus infectivity, antigenicity and immunogenicity is discussed in the light of the results of our previous and present investigations.
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