Antibacterial effects of some 1-substituted 1,2,4-triazoles
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
9569632
DOI
10.1007/bf02815548
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Bacteria drug effects MeSH
- Gram-Negative Bacteria drug effects MeSH
- Gram-Positive Bacteria drug effects MeSH
- Enzyme Inhibitors pharmacology MeSH
- Microbial Sensitivity Tests MeSH
- Triazoles chemistry pharmacology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- 1,2,4-triazole MeSH Browser
- Anti-Bacterial Agents MeSH
- Enzyme Inhibitors MeSH
- Triazoles MeSH
Seventeen synthetic 1-substituted 1,2,4-triazoles exerted a significant effect on the bacteria B. subtilis, S. aureus, E. coli and P. aeruginosa. The least sensitive to the effects of the triazoles was S. aureus. With all triazole derivatives and their combinations, B. subtilis and P. aeruginosa exhibited IC50 and MIC values several times higher than with ampicillin. The most effective triazoles have a N-phenyl ring or benzimidinoyl ring substituted with one or several chlorine atoms. The highest tested concentration of the three most effective triazoles influenced the specific growth rate.
In vitro antimicrobial activity of 3,4-dihydro-s-triazinobenzimidazole derivatives
Antibacterial effects of trisubstituted quinazoline derivatives
