Mapping of selective rat chromosome regions using mouse microsatellite markers
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
PubMed
9595259
Knihovny.cz E-resources
- MeSH
- Species Specificity MeSH
- Genetic Linkage MeSH
- Hypertension genetics MeSH
- Rats, Inbred Strains genetics MeSH
- Blood Pressure genetics MeSH
- Rats MeSH
- Quantitative Trait, Heritable * MeSH
- Chromosome Mapping * MeSH
- Microsatellite Repeats * MeSH
- Mice MeSH
- Polymorphism, Genetic MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
Four hundred eighty mouse microsatellite markers distributed in discrete regions on five mouse chromosomes were screened for producing PCR products in the rat. Ninety-eight of these markers or 20% give distinctive PCR products. Among these ninety-eight markers, twenty-three are polymorphic between the inbred hypertensive Dahl salt-sensitive (S) rat strain and several normotensive rat strains of interest. Fourteen of these polymorphic markers have been mapped to the homologous chromosome regions of the rat, and have further been utilized to localize quantitative trait loci (QTL) for blood pressure in the S rat.
