Quantification of ammonia in human breath by the selected ion flow tube analytical method using H30+ and 02+ precursor ions
Language English Country Great Britain, England Media print
Document type Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
PubMed
9650302
DOI
10.1002/(sici)1097-0231(19980630)12:12<763::aid-rcm229>3.0.co;2-s
PII: 10.1002/(SICI)1097-0231(19980630)12:12<763::AID-RCM229>3.0.CO;2-S
Knihovny.cz E-resources
- MeSH
- Ammonia analysis MeSH
- Breath Tests methods MeSH
- Dietary Proteins metabolism MeSH
- Oxygen chemistry MeSH
- Humans MeSH
- Pulmonary Alveoli metabolism MeSH
- Water analysis MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Ammonia MeSH
- Dietary Proteins MeSH
- Oxygen MeSH
- Water MeSH
We show how our selected ion flow tube mass spectrometric technique for trace gas analysis can be used to determine the concentrations of ammonia in alveolar breath from single exhalations using both H30+ and 02+ precursor ions for chemical ionization. Thus, data are presented of the alveolar ammonia concentrations in the breath of six healthy volunteers following the ingestion of a liquid protein meal, which show that consistent values are obtained using these two precursor ions. Alveolar breath ammonia concentrations (which range from 200 to 1750 ppb in these individuals) are compared with those obtained from bag samples of breath from the same individuals.
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