The study focused on some problems connected with the formulation of the topical preparation of the hydrocream type, intended for the treatment of dermal burns. Seven cream bases containing Emulgator E 2155, Polysorbate 80 and silicone oils were evaluated. The employed drugs included carbizocaine, lidocaine, chlorohexidine, and the immunomodulating substance glucan. A measurement of the surface tension of chlorohexidine and carbizocaine did not reveal interaction between these two drugs. Liberation tests confirmed a higher release of lidocaine in comparison with carbizocaine and chlorohexidine. The silicone oil present did not influence the release of carbizocaine, but it promoted the release of lidocaine and chlorohexidine. The determination of rheological parameters revealed that an addition of drugs influenced the flow properties of creams. The suitability of cream ointments was evaluated on the basis of their drying.

Katedra galenickej farmácie Farmaceutickej fakulty Univerzity Komenského Bratislava