Can Cerebrolysin influence chronic deterioration of spatial learning and memory?
Jazyk angličtina Země Rakousko Médium print
Typ dokumentu časopisecké články
- MeSH
- aminokyseliny terapeutické užití MeSH
- chování zvířat účinky léků MeSH
- krysa rodu Rattus MeSH
- nootropní látky terapeutické užití MeSH
- poranění mozku komplikace patologie psychologie MeSH
- poruchy paměti farmakoterapie etiologie MeSH
- poruchy učení farmakoterapie etiologie MeSH
- potkani Long-Evans MeSH
- vnímání prostoru účinky léků MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- aminokyseliny MeSH
- cerebrolysin MeSH Prohlížeč
- nootropní látky MeSH
Our previous studies showed that the nootropic drug Cerebrolysin, applied immediately after the traumatic or excitotoxic brain lesion influenced spatial learning and memory. Long-lasting ameliorative effect of Cerebrolysin was found after its 4-week-administration, while two-week-treatment had only temporal effect. With the aim to verify the capability of Cerebrolysin to restore chronically deteriorated learning and memory. The drug was applied 4 months after lesioning the rat's CNS. The present study shows that Cerebrolysin restored learning capability of the lesioned rats. Although their spatial memory was improved in comparison to lesion untreated controls, it did not reach the level of intact controls. The effect was more pronounced after the application of 1.25 ml/kg b. w. of Cerebrolysin than after the application of 2.5 ml/kg b. w.
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