Estimation of apoptosis in C6 glioma cells treated with antidepressants
Physiological research.
1997 ;
46 (2) :
161-4.
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/pmid09727508
PubMed
9727508
Knihovny.cz E-resources
- MeSH
- Amitriptyline pharmacology MeSH
- Antidepressive Agents pharmacology MeSH
- Apoptosis * MeSH
- Fluoxetine pharmacology MeSH
- DNA Fragmentation drug effects MeSH
- Glioma pathology MeSH
- Imipramine pharmacology MeSH
- Humans MeSH
- Tumor Cells, Cultured MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Amitriptyline MeSH
- Antidepressive Agents MeSH
- Fluoxetine MeSH
- Imipramine MeSH
Gel electrophoresis of DNA was used for estimation of DNA changes caused in C6 glioma cells by treatment with psychotropic drugs (imipramine, amitryptiline and fluoxetine). Some discrete bands containing a population of short DNA fragments appeared after 1 and 5 days of cultivation. Apoptotic DNA breaks were verified at single cell level using the TUNEL test in cells treated with fluoxetine.
