Regionální chemoterapie u experimentálního cholangiokarcinomu veprů
[Regional chemotherapy in experimental cholangiocarcinoma in pigs]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
9748745
- MeSH
- Chemotherapy, Cancer, Regional Perfusion * MeSH
- Cholangiocarcinoma drug therapy MeSH
- Bile Duct Neoplasms drug therapy MeSH
- Swine MeSH
- Antineoplastic Combined Chemotherapy Protocols therapeutic use MeSH
- Bile Ducts, Intrahepatic * MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
BACKGROUND: Primary cholangiocarcinoma (PCC) accounts for cca 9% of all carcinomas of the liver and biliary system. Its prognosis of always unfavourable and treatment is difficult. METHODS AND RESULTS: In 25 pigs strain BU PCC was induced chemically with the aim to test the action of regional chemotherapy on the tumor tissue. For treatment 5-fluorouracil, 5-fluoro-2-deoxyuridine, mitomycin C and doxorubicin was used either as monotherapy or in combinations. During chemotherapy a significant reduction of the tumour or fibrotization occurred, as compared with animals not receiving treatment. The median of survival was prolonged from 51.3 to 210.3 days. CONCLUSIONS: Regional chemotherapy is a significant constituent of oncological treatment of PCC. Complications of treatment are negligible and the rest for further treatment are encouraging.
