Selektivní modulátory estrogenních receptorů jako nová koncepce odvrácení zdravotních rizik menopauzy
[Selective estrogen receptor modulators as a new concept in preventing health risks of menopause]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
9929934
- MeSH
- Estrogen Antagonists pharmacology MeSH
- Dementia prevention & control MeSH
- Estrogen Replacement Therapy MeSH
- Estrogens agonists MeSH
- Cardiovascular Diseases prevention & control MeSH
- Humans MeSH
- Menopause * MeSH
- Osteoporosis, Postmenopausal prevention & control MeSH
- Receptors, Estrogen drug effects MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Estrogen Antagonists MeSH
- Estrogens MeSH
- Receptors, Estrogen MeSH
Long-term estrogen deficiency after menopause is responsible for different disorders, which not only make the quality of life in the older age worse but also are the major causes of women's mortality. It is especially the case for cardiovascular disease, osteoporosis and dementia. The risk for these disorders can significantly be reduced by hormone replacement therapy (HRT). Unfortunately, the mean duration of the postmenopausal administration of HRT is too short to demonstrate its efficacy in preventing the mentioned diseases. In this review the new therapeutic possibilities are discussed, called selective estrogen receptor modulators (SERMs). These structurally heterogeneous compounds interact with estrogen receptors and act as either estrogen-agonists or--antagonists according to the type of organ and physiological context (i.e., dose, target tissue and hormone concentration in the tissue). The evaluation of the effects of these compounds led to the better understanding of both antiestrogens and the whole steroid signaling system. The research of the clinical properties of SERM showed their potential benefit in the long-term care of the women in their non-reproductive period of life and demonstrated the possibility to overcome some drawbacks of HRT.