Effect of peroral anti-bacterial antiserum treatment on intestinal immune parameters of germ-free piglets intragastrically infected with virulent Salmonella typhimurium or enteropathogenic E. coli
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
9950354
DOI
10.1016/s0165-2427(98)00208-6
PII: S0165-2427(98)00208-6
Knihovny.cz E-resources
- MeSH
- Immune Sera administration & dosage immunology MeSH
- Administration, Oral MeSH
- Escherichia coli immunology pathogenicity MeSH
- Fluorescent Antibody Technique MeSH
- Germ-Free Life immunology MeSH
- Ileitis immunology microbiology veterinary MeSH
- Escherichia coli Infections immunology veterinary MeSH
- Swine Diseases immunology microbiology MeSH
- Swine MeSH
- Salmonella typhimurium immunology pathogenicity MeSH
- Salmonella Infections, Animal immunology MeSH
- Intestinal Mucosa immunology microbiology MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Immune Sera MeSH
Germ-free piglets were orally infected with either enteropathogenic E. coli 055 or a virulent strain of Salmonella typhimurium. Orally applied antiserum against E. coli protected infected animals in spite of the fact that the bacteria were consistently found in mesenteric lymph nodes and other organs. By contrast, the application of an antiserum against S. typhimurium was without any effect on the outcome of infection. The treatment with anti-bacterial antiserum prevented inflammation of ileal mucosa (TNF-alpha and heat shock protein 65 expression) only in piglets infected with E. coli. A decrease in the frequency of ileal MAC320+ cells was observed in all infected piglets treated with antiserum.
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