The interaction of immunomodulatory muramyl dipeptide with peripheral 5-HT receptors: overview of the current state
Language English Country England, Great Britain Media print
Document type Journal Article, Review
PubMed
10348372
DOI
10.1016/s0192-0561(98)00079-4
PII: S0192056198000794
Knihovny.cz E-resources
- MeSH
- Acetylmuramyl-Alanyl-Isoglutamine pharmacology MeSH
- Adjuvants, Immunologic pharmacology MeSH
- Humans MeSH
- Receptors, Serotonin classification drug effects physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Acetylmuramyl-Alanyl-Isoglutamine MeSH
- Adjuvants, Immunologic MeSH
- Receptors, Serotonin MeSH
Immunomodulator muramyl dipeptide (MDP) exerts also pronounced neuropharmacological activities which are probably mediated by an interaction with 5-HT receptors. Some of these effects are considered as undesirable by its clinical use. More precise information concerning MDP effects on 5-HT receptors with respect to their many subtypes could result from studies using isolated organs in vitro. Earlier conducted studies of this type provided data that are concisely overviewed and reinterpreted here from the view of current 5-HT receptor classification. Since new 5-HT receptor types have emerged recently, new studies are under way. The results might contribute to the development of novel immunomodulatory drugs devoid of adverse effects.
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