Autoantibodies against oxidized LDL in the first phase of life. Low density lipoproteins
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
10596958
DOI
10.1515/cclm.1999.135
Knihovny.cz E-resources
- MeSH
- Autoantibodies analysis MeSH
- Cholesterol blood MeSH
- Humans MeSH
- Lipoproteins, LDL immunology MeSH
- Malondialdehyde blood MeSH
- Infant, Newborn blood immunology MeSH
- Oxidative Stress MeSH
- Superoxide Dismutase blood MeSH
- Free Radicals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Infant, Newborn blood immunology MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Autoantibodies MeSH
- Cholesterol MeSH
- Lipoproteins, LDL MeSH
- Malondialdehyde MeSH
- oxidized low density lipoprotein MeSH Browser
- Superoxide Dismutase MeSH
- Free Radicals MeSH
The study presents a comparison of data concerning lipid metabolism and lipid oxidation (oxidative stress) in children at the time of their birth and 3 months later, as well as of their mothers at the time of delivery, compared to a control group of non-pregnant women of the same age. The data confirm that labour represents an oxidative stress for both mother and child; it is expressed as a significant increase of malondialdehyde concentration in mothers immediately after delivery in comparison with non-pregnant women (p<0.001). Its concentration in newborns was even higher than in their mothers (p<0.005). Concentration of antibodies against oxidized LDL (oxLDLAb) was comparable in mothers and newborns due to their transplacental transport. During the first three months of life these autoantibodies increased almost two-fold. The importance of this unique observation is discussed with respect to possible early atherogenesis.
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