The influence of different types of antibodies on in vitro fertilization results
Language English Country Denmark Media print
Document type Journal Article
- MeSH
- Antibodies, Antiphospholipid metabolism MeSH
- Autoantibodies metabolism MeSH
- Fertilization in Vitro * MeSH
- Immunoassay MeSH
- Infertility immunology therapy MeSH
- Sperm Injections, Intracytoplasmic MeSH
- Humans MeSH
- Antibodies metabolism MeSH
- Spermatozoa immunology MeSH
- Pregnancy MeSH
- Zona Pellucida immunology MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antibodies, Antiphospholipid MeSH
- Autoantibodies MeSH
- Antibodies MeSH
PROBLEM: The influence of anti-sperm (ASA), anti-phospholipid (APA), and antizonal (AZA) antibodies on in vitro fertilization (IVF) results and the need for intracytoplasmic sperm injection (ICSI) were assessed. METHOD OF STUDY: Forty-four couples with infertility of immunologic origin were investigated. ASA in serum and ovulatory mucus were studied by a tray agglutination test (TAT) and indirect mixed anti-globulin reaction test (MAR) test, AZA were studied by passive hemagglutination and commercial enzyme-linked immunosorbent assay (ELISA; BioGen, Germany), and APA were tested by ELISAs in immunoglobulin isotypes IgG and IgM. RESULTS: Because of failed or very low fertilization after standard IVF in the previous cycle, ICSI had to be used in five out of 15 cases with ASA (33.3%), in 16 out of 18 couples with AZA (89.4%), and in only one case if APA were present (9%). Clinical pregnancy rate was 60% in cases with ASA, 38.5% with AZA, and 27.3% per embryo transfer (ET) if APA were detected. CONCLUSIONS: Immunologic infertility can be treated by IVF with very good results. The most important group are women with AZA, in whom IVF ICSI without any delay is recommended.
References provided by Crossref.org
The role of antiphospholipid antibodies (aPls) in infertile women: the long-lasting experience
