Effect of 7-methoxytacrine and L-carnitine on the activity of choline acetyltransferase
Language English Country Slovakia Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
10703712
Knihovny.cz E-resources
- MeSH
- Basal Ganglia enzymology MeSH
- Choline O-Acetyltransferase metabolism MeSH
- Hippocampus enzymology MeSH
- Carnitine pharmacology MeSH
- Kinetics MeSH
- Rats MeSH
- Neurons enzymology MeSH
- Rats, Wistar MeSH
- Tacrine analogs & derivatives pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 7-methoxytacrine MeSH Browser
- Choline O-Acetyltransferase MeSH
- Carnitine MeSH
- Tacrine MeSH
Changes of choline acetyltransferase (ChAT) activity in the hippocampus and the basal ganglia were studied in rats treated i.p. with L-carnitine (CRT) and 7-methoxytacrine (7-MEOTA) (i.m.) separately or 3-days treated with L-carnitine and then with one administration of 7-MEOTA. Both compounds increased ChAT activity when administered separately. 3-day treatment of CRT followed by administration of 7-MEOTA normalized ChAT activity.
