Comparison of pancreatic and hypophysiotropic TRH systems
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
10984074
Knihovny.cz E-resources
- MeSH
- Potassium Chloride pharmacology MeSH
- Median Eminence drug effects metabolism MeSH
- Glucose pharmacology MeSH
- Thyrotropin-Releasing Hormone metabolism MeSH
- Hypothalamus drug effects metabolism MeSH
- Rats MeSH
- Cells, Cultured MeSH
- Islets of Langerhans drug effects metabolism MeSH
- Paraventricular Hypothalamic Nucleus drug effects metabolism MeSH
- Rats, Wistar MeSH
- Calcium pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Potassium Chloride MeSH
- Glucose MeSH
- Thyrotropin-Releasing Hormone MeSH
- Calcium MeSH
The thyrotropin-releasing hormone (TRH) is a molecule with widespread distribution through many organ systems. The function of TRH is probably not identical in each system so that TRH synthesis and secretion may be unique for each system under specific experimental conditions. The present study was designed to explore the common and diverse features of the regulation of TRH encoded with the same gene in two different organs: hypophysiotropic hypothalamus and pancreatic islets. During in vitro incubation, the TRH content in hypothalamic structures remained stable while that in isolated pancreatic islets increased sharply. In contrast to the pancreatic islets, exposure to different concentrations of D-glucose did not affect TRH release from the hypothalamic paraventricular nucleus or median eminence. This divergence in the regulation of the hypophysiotropic and pancreatic TRH systems may be related to differences in the role of TRH produced in these tissues.
