Suppressing aggressive behavior with analogs of allopregnanolone (epalon)
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11146089
DOI
10.1016/s0039-128x(00)00215-4
PII: S0039-128X(00)00215-4
Knihovny.cz E-resources
- MeSH
- Aggression drug effects MeSH
- Mice, Inbred ICR MeSH
- Mice MeSH
- Pregnanolone analogs & derivatives pharmacology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Pregnanolone MeSH
3alpha-Hydroxy-20-oxo-5alpha-pregnan-21-yl hemisuccinate (8) was produced by partial acylation of 3alpha,21-dihydroxy-5alpha-pregnan-20-one (14). 3alpha-Fluoro-5alpha-pregnan-20-one (9) was prepared by treatment of 3beta-hydroxy-5alpha-pregnan-20-one (11) with DAST and by solvolysis of tosylate 12 with tetrabutylammonium fluoride. A behavioral test on mice was performed using 3alpha-hydroxy-5alpha-pregnan-20-one (1) and compounds 8 and 9. Compound 8 was found to be inactive, while the fluoro derivative 9 selectively reduced aggressive behavior in mice more than the corresponding 3alpha-hydroxy compound 1; locomotion and other behavioral features were not affected.
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