Isoquinoline alkaloids from Mahonia aquifolium stem bark are active against Malassezia spp
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11501395
DOI
10.1007/bf02873586
Knihovny.cz E-resources
- MeSH
- Alkaloids isolation & purification pharmacology MeSH
- Antifungal Agents isolation & purification pharmacology MeSH
- Dermatomycoses microbiology MeSH
- Isoquinolines isolation & purification pharmacology MeSH
- Plant Bark chemistry MeSH
- Mahonia chemistry MeSH
- Malassezia drug effects MeSH
- Microbial Sensitivity Tests MeSH
- Pityriasis microbiology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Alkaloids MeSH
- Antifungal Agents MeSH
- Isoquinolines MeSH
Bioassay directed fractionation of crude extract from Mahonia aquifolium led to the isolation of fraction A (bisbenzylisoquinoline alkaloid complex, BBI) and a fraction of protoberberine alkaloids, where the major compounds berberine and jatrorrhizine were isolated as their iodides. The antifungal activity of the crude extract, two protoberberine alkaloids and BBI from M. aquifolium stem bark were evaluated against six strains of Malassezia spp. The compounds tested were generally found to possess only weak to moderate antifungal properties: the MICs for individual strains were in the range < or = 50-> or = 1000 mg/L.
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