Combination of drugs elevating extracellular adenosine with granulocyte colony-stimulating factor promotes granulopoietic recovery in the murine bone marrow after 5-fluorouracil treatment
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11702857
Knihovny.cz E-resources
- MeSH
- Adenosine metabolism MeSH
- Adenosine Monophosphate administration & dosage MeSH
- Bone Marrow Cells MeSH
- Dipyridamole administration & dosage MeSH
- Extracellular Space metabolism MeSH
- Granulocyte Colony-Stimulating Factor administration & dosage MeSH
- Fluorouracil pharmacology MeSH
- Granulocytes * MeSH
- Hematopoietic Stem Cells drug effects MeSH
- Hematopoiesis drug effects MeSH
- Bone Marrow drug effects MeSH
- Drug Interactions MeSH
- Humans MeSH
- Macrophages MeSH
- Mice MeSH
- Recombinant Proteins administration & dosage MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adenosine MeSH
- Adenosine Monophosphate MeSH
- Dipyridamole MeSH
- Granulocyte Colony-Stimulating Factor MeSH
- Fluorouracil MeSH
- Recombinant Proteins MeSH
Combined administration of drugs elevating extracellular adenosine, namely dipyridamole and adenosine monophosphate, together with granulocyte colony-stimulating factor was shown to enhance granulopoietic recovery in the bone marrow of mice treated with 5-fluorouracil. Enhanced regeneration was found both at the level of hematopoietic progenitor cells for granulocytes and macrophages and in the compartment of morphologically recognizable granulocyte precursors. The results might have positive clinical impact. The adjunct use of drugs elevating extracellular adenosine might reduce the cost expenditure of therapy with granulocyte colony-stimulating factor.
The role of adenosine receptor agonists in regulation of hematopoiesis
