Phenolic acids reduce the genotoxicity of acridine orange and ofloxacin in Salmonella typhimurium
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11898340
DOI
10.1007/bf02817994
Knihovny.cz E-resources
- MeSH
- Acridine Orange toxicity MeSH
- Antimutagenic Agents pharmacology MeSH
- Gentisates * MeSH
- Hydroxybenzoates pharmacology MeSH
- Caffeic Acids pharmacology MeSH
- Coumaric Acids pharmacology MeSH
- Mutagens toxicity MeSH
- Ofloxacin toxicity MeSH
- Propionates MeSH
- Salmonella typhimurium drug effects genetics MeSH
- Mutagenicity Tests MeSH
- Dose-Response Relationship, Drug MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 2,5-dihydroxybenzoic acid MeSH Browser
- Acridine Orange MeSH
- Antimutagenic Agents MeSH
- caffeic acid MeSH Browser
- ferulic acid MeSH Browser
- Gentisates * MeSH
- Hydroxybenzoates MeSH
- Caffeic Acids MeSH
- Coumaric Acids MeSH
- Mutagens MeSH
- Ofloxacin MeSH
- p-coumaric acid MeSH Browser
- phenolic acid MeSH Browser
- Propionates MeSH
Naturally occurring plant phenolics, p-coumaric acid (PA), caffeic acid (CA), ferulic acid (FA) and gentisic acid (GA) (25-100 nmol/L) had protective effects on acridine orange (AO; 216 mumol/L)- and ofloxacin (3 mumol/L)-induced genotoxicity in Salmonella typhimurium. FA, GA and CA exhibited a significant concentration-dependent protective effect against the genotoxicity of AO and ofloxacin, with the exception of PA, which at all concentrations tested abolished the AO and ofloxacin genotoxicity. UV spectrophotometric measurements showed the interaction of PA, FA, GA and CA with AO but not with ofloxacin; this interaction is obviously responsible for the reduction of AO-induced S. typhimurium mutagenicity. In the case of ofloxacin the antimutagenic effect of PA, FA, GA and CA is assumed to be a result of their ability to scavenge reactive oxygen species (ROS) produced by ofloxacin.
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