Development of hydrogel implants for urinary incontinence treatment
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12109696
DOI
10.1016/s0142-9612(02)00104-7
PII: S0142-9612(02)00104-7
Knihovny.cz E-resources
- MeSH
- Colony-Forming Units Assay MeSH
- Hematopoiesis MeSH
- Hydrogels * MeSH
- Urinary Incontinence pathology surgery MeSH
- Cells, Cultured MeSH
- Methacrylates MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Prostheses and Implants * MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Hydrogels * MeSH
- hydroxyethyl methacrylate MeSH Browser
- Methacrylates MeSH
Hydrogel implants for urinary incontinence treatment based on HEMA supplemented with 10% methacrylic acid have been developed. The swelling properties of implants were tested in vitro and in vivo after implantation to laboratory mice. Biocompatibility has been determined by incubation of implants in tissue culture, by histological examination of adjacent tissues after subcutaneous application of implants to laboratory mouse in a long-term experiment, and by flow cytometry examination of blood cells. The swelling of hydrogel implants was completed in 6-24 h. There was no effect on in vitro growth of cells incubated with implants. In mice, implants were well tolerated without any sign of inflammatory reaction. The material allows an elastic compression of urethra compensating a damaged sphincter after trans-urethral sub-mucosal implantation of hydrogel cylinders.
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