At present, it seems clear that the nucleolus is multifunctional and represents one of the key cell organelles that participate directly or indirectly in cell resting, proliferation, differentiation and maturation states, and possibly also in programmed cell death. Thus, the morphology and cytochemistry of nucleoli may represent a very useful tool not only for the evaluation of nucleolar biosynthetic activities but also for the evaluation of various cell states under physiological, experimental and pathological conditions.

Clinical Section Institute of Hematology and Blood Transfusion Prague Czech Republic

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The cell body space occupied by the nucleus during the cell differentiation in human lymphocytic, granulocytic and erythroid cell lineages

To the intranucleolar translocation of AgNORs in leukemic early granulocytic and plasmacytic precursors