Hematopoiesis-stimulating and anti-tumor effects of repeated administration of diclofenac in mice with transplanted fibrosarcoma cells
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12511188
Knihovny.cz E-resources
- MeSH
- Anti-Inflammatory Agents, Non-Steroidal pharmacology therapeutic use MeSH
- Diclofenac pharmacology therapeutic use MeSH
- Sarcoma, Experimental drug therapy MeSH
- Fibrosarcoma drug therapy MeSH
- Hematopoiesis drug effects MeSH
- Mice, Inbred C3H MeSH
- Mice MeSH
- Tumor Cells, Cultured MeSH
- Drug Evaluation, Preclinical MeSH
- Neoplasm Transplantation MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Inflammatory Agents, Non-Steroidal MeSH
- Diclofenac MeSH
Positive effects of repeated administration of diclofenac, an inhibitor of prostaglandin synthesis, in terms of prevention of tumor development and stimulation of hematopoiesis have been observed in C3H mice transplanted subcutaneously with G:5:113 fibrosarcoma cells. Fourteen-day treatment with diclofenac (3.75 microg/kg/day) started from day 5 after tumor cell transplantation. Measurements of tumors and hematological examinations were performed on day 30. The results strongly suggest the possibility that inhibitors of prostaglandin synthesis (non-steroidal anti-inflammatory drugs) may be used in oncological practice where the observed effects are highly desirable.
Stimulatory action of cyclooxygenase inhibitors on hematopoiesis: a review
