Synthesis and pharmacological evaluation of novel potential ultrashort-acting beta-blockers
Die Pharmazie.
2003 Jan ;
58 (1) :
18-21.
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/pmid12622246
PubMed
12622246
Knihovny.cz E-resources
- MeSH
- Adrenergic beta-Agonists pharmacology MeSH
- Anti-Arrhythmia Agents chemical synthesis pharmacology MeSH
- Adrenergic beta-Antagonists chemical synthesis pharmacology MeSH
- Muscle, Smooth drug effects MeSH
- Isoproterenol antagonists & inhibitors pharmacology MeSH
- Myocardial Contraction drug effects MeSH
- Magnetic Resonance Spectroscopy MeSH
- Guinea Pigs MeSH
- Ouabain antagonists & inhibitors toxicity MeSH
- Propanolamines chemical synthesis pharmacology MeSH
- Spectrophotometry, Infrared MeSH
- Spectroscopy, Fourier Transform Infrared MeSH
- Arrhythmias, Cardiac chemically induced prevention & control MeSH
- Heart Rate drug effects MeSH
- Muscle Contraction drug effects MeSH
- In Vitro Techniques MeSH
- Trachea drug effects MeSH
- Animals MeSH
- Check Tag
- Guinea Pigs MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adrenergic beta-Agonists MeSH
- Anti-Arrhythmia Agents MeSH
- Adrenergic beta-Antagonists MeSH
- Isoproterenol MeSH
- Ouabain MeSH
- Propanolamines MeSH
The basic relationship between chemical structure and pharmacological activity of eight newly developed potential ultrashort-acting beta-adrenergic blockers was evaluated. The compounds studied are derivatives of arylcarbonyloxyaminopropanols and were prepared by four-step synthesis. All the compounds evaluated showed weak antiisoprenaline (beta-adrenergic receptor blocking) activity and antiarrhythmic (antiouabain) activity.
Molecules (Basel, Switzerland).
2017 Nov 23 ;
22 (12) :
.
[epub] 20171123
Molecules (Basel, Switzerland).
2016 Jun 01 ;
21 (6) :
.
[epub] 20160601
TheScientificWorldJournal.
2013 ;
2013 () :
274570.
[epub] 20131029
