The role of the IKAP gene polymorphisms in atopic diseases in the middle European population
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
12774215
DOI
10.1007/s10038-003-0028-0
PII: 10.1007/s10038-003-0028-0
Knihovny.cz E-zdroje
- MeSH
- alely MeSH
- atopická dermatitida genetika MeSH
- běloši genetika MeSH
- bronchiální astma genetika MeSH
- celoroční alergická rýma genetika MeSH
- dospělí MeSH
- genetická variace MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- polymorfismus genetický * MeSH
- studie případů a kontrol MeSH
- transkripční elongační faktory MeSH
- transportní proteiny genetika MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- Elp1 protein, human MeSH Prohlížeč
- transkripční elongační faktory MeSH
- transportní proteiny MeSH
Over ten genome-wide screens and many candidate genes studies were performed worldwide to elucidate genetic factors involved in the pathogenesis of bronchial asthma and other atopic diseases. Results from these studies were often discordant, which might have reflected complexity and heterogeneity of these multifactorial diseases. Among a variety of other loci, specific variants of the gene for IKAP (IKK complex-associated protein) were shown to be associated with bronchial asthma in children in a Japanese study. To test the possible role of SNPs in the coding region of the IKAP gene in atopic asthma or other atopic phenotypes in a highly homogenous Czech population, a case-control study including 373 patients and 309 healthy control subjects was performed. There were no significant differences in the genotype and allele distributions for any of five SNPs in the IKAP gene (T819C, G2295A, A2490G, T3214A and C3473T) between patients with atopic asthma or other atopic diseases and healthy controls. These results suggest that the polymorphisms in the coding region of the IKAP gene are unlikely to contribute to atopic disease risk in the Czech population.
2nd Department of Paediatrics Faculty Children Hospital Brno Czech Republic
Department of Obstetrics and Gynecology Hospital Vyskov Czech Republic
Zobrazit více v PubMed
Am J Hum Genet. 2001 Mar;68(3):753-8 PubMed
Nature. 1998 Sep 17;395(6699):292-6 PubMed
J Allergy Clin Immunol. 1999 Dec;104(6):1139-46 PubMed
Am J Hum Genet. 1988 Jan;42(1):113-24 PubMed
Oncogene. 1999 Nov 22;18(49):6853-66 PubMed
J Biol Chem. 2002 Jan 25;277(4):3047-52 PubMed
J Hum Genet. 2001;46(2):57-63 PubMed
Am J Hum Genet. 2001 Mar;68(3):598-605 PubMed
J Investig Allergol Clin Immunol. 2002;12(3):192-7 PubMed
Genomics. 1999 May 15;58(1):1-8 PubMed
J Biol Chem. 2000 Sep 22;275(38):29779-87 PubMed
J Biol Chem. 2002 Aug 30;277(35):31918-28 PubMed
Allergy. 2001 Sep;56(9):813-24 PubMed
