Atypical hemispheric language dominance in left temporal lobe epilepsy as a result of the reorganization of language functions
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
12899862
DOI
10.1016/s1525-5050(03)00119-7
PII: S1525505003001197
Knihovny.cz E-resources
- MeSH
- Dominance, Cerebral * MeSH
- Adult MeSH
- Electroencephalography MeSH
- Epilepsy, Temporal Lobe diagnosis physiopathology surgery MeSH
- Injections, Intra-Arterial MeSH
- Language * MeSH
- Language Tests MeSH
- Tomography, Emission-Computed, Single-Photon MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Methohexital administration & dosage MeSH
- Adolescent MeSH
- Brain physiopathology MeSH
- Neuronal Plasticity MeSH
- Retrospective Studies MeSH
- Age of Onset MeSH
- Videotape Recording MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Methohexital MeSH
Hemispheric language dominance, as determined by intracarotid short-acting barbiturate injections (Wada testing), was retrospectively evaluated in 44 right-handed patients with medically intractable left (n=26) or right (n=18) temporal lobe epilepsy (TLE). Atypical hemispheric language dominance (right or bilateral) was revealed in 13.6% of all patients investigated. A significantly higher rate of deviance from complete left hemisphere dominance was observed in left TLE (23.1%) than in right TLE (0%). Patient age at the time of seizure onset was proven a critical variable affecting atypical speech development in left TLE. The mean patient age at the time of seizure onset in left TLE patients with atypical language representation was 5.61 years, but was 13.13 years in patients with left hemisphere language dominance. Our results strongly support the influential impact of epileptiform activity spreading from the left temporal lobe structures on the reorganization of language functions in patients with early brain injury.
References provided by Crossref.org
Third International Congress on Epilepsy, Brain and Mind: Part 1
