Antikomplementová aktivita saponínov z Cynara cardunculus L
[Anticomplement activity of saponins from Cynara cardunculus L]
Language Slovak Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't
PubMed
14661371
- MeSH
- Cynara * chemistry MeSH
- Complement Pathway, Classical drug effects MeSH
- Guinea Pigs MeSH
- Saponins chemistry pharmacology MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Guinea Pigs MeSH
- Animals MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Saponins MeSH
Triterpene saponins of ursane and oleane type isolated from the involucral bracts of Cynara cardunculus L. (Asteraceae) were investigated in in vitro assays for their activity on the complement system. The anticomplementary activity of bidesmosidic saponins on the classical pathway activation of the complement was higher than the activity of monodesmosidic saponins, but esterification of the carboxylic group of glucuronic acid in the sugar residue resulted in a significant decrease in anticomplementary activity.
