Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.

DUI

D003171 MeSH Browser

CUI

M0004923

Previous indexing

Complement (1966-1978); Complement Fixation Tests (1966-1978)

History note

91(79); was see under COMPLEMENT ACTIVATION 1979-90

Public note

91; was see under COMPLEMENT ACTIVATION 1979-90