Mikrodelécie chromozómu Y u ceských muzov s t'azkou poruchou reprodukcie
[Chromosome Y microdeletions in Czech men with severe reproductive disorders]
Jazyk slovenština Země Česko Médium print
Typ dokumentu anglický abstrakt, časopisecké články, práce podpořená grantem
PubMed
14689827
- MeSH
- delece genu * MeSH
- genetické lokusy MeSH
- lidé MeSH
- lidský chromozom Y genetika MeSH
- mužská infertilita genetika MeSH
- oligospermie genetika MeSH
- proteiny semenné plazmy genetika MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- proteiny semenné plazmy MeSH
BACKGROUND: The Y chromosome microdeletions belong to the frequent genetical causes of male infertility. The aim of our study was to introduce reliable molecular genetic diagnosis of Y chromosomal microdeletions and to determine the prevalence of Y chromosomal microdeletions in Czech males with serious reproductive disorders. METHODS AND RESULTS: The Y chromosome microdeletions were screened in 198 Czech men with serious reproductive disorders with decreased sperm count. The Y chromosome microdeletions were disclosed in 8/198 (4.0%) examined males. The AZFc deletion type was revealed in 62.5% (5/8) and the combined AZFc + b microdeletion in 37.5% (3/8) of cases. Neither isolated AZFb nor AZFa microdeletion were found in any subject of the investigated group. CONCLUSIONS: Incidence of individual types of Y chromosomal microdeletions in Czech males with serious reproductive disorders was assessed. The standardised molecular genetic diagnosis of Y chromosomal microdeletions was introduced into the practice.
