Mikrodelécie chromozómu Y u ceských muzov s t'azkou poruchou reprodukcie
[Chromosome Y microdeletions in Czech men with severe reproductive disorders]
Language Slovak Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't
PubMed
14689827
- MeSH
- Gene Deletion * MeSH
- Genetic Loci MeSH
- Humans MeSH
- Chromosomes, Human, Y genetics MeSH
- Infertility, Male genetics MeSH
- Oligospermia genetics MeSH
- Seminal Plasma Proteins genetics MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Seminal Plasma Proteins MeSH
BACKGROUND: The Y chromosome microdeletions belong to the frequent genetical causes of male infertility. The aim of our study was to introduce reliable molecular genetic diagnosis of Y chromosomal microdeletions and to determine the prevalence of Y chromosomal microdeletions in Czech males with serious reproductive disorders. METHODS AND RESULTS: The Y chromosome microdeletions were screened in 198 Czech men with serious reproductive disorders with decreased sperm count. The Y chromosome microdeletions were disclosed in 8/198 (4.0%) examined males. The AZFc deletion type was revealed in 62.5% (5/8) and the combined AZFc + b microdeletion in 37.5% (3/8) of cases. Neither isolated AZFb nor AZFa microdeletion were found in any subject of the investigated group. CONCLUSIONS: Incidence of individual types of Y chromosomal microdeletions in Czech males with serious reproductive disorders was assessed. The standardised molecular genetic diagnosis of Y chromosomal microdeletions was introduced into the practice.
