Two plant alkaloids isolated from Corydalis longipes as potential antifungal agents
Language English Country United States Media print
Document type Journal Article
PubMed
14976716
DOI
10.1007/bf02993466
Knihovny.cz E-resources
- MeSH
- Alkaloids chemistry isolation & purification pharmacology MeSH
- Antifungal Agents chemistry isolation & purification pharmacology MeSH
- Corydalis chemistry MeSH
- Fungi drug effects growth & development MeSH
- Plant Preparations chemistry MeSH
- Spores, Fungal drug effects MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Alkaloids MeSH
- Antifungal Agents MeSH
- Plant Preparations MeSH
The alkaloids N-methylhydrasteine hydroxylactam and 1-methoxyberberine chloride were isolated from Corydalis longipes. Both alkaloids showed high efficacy individually (in concentration of 50-150 ppm) and also in a 1:1 mixture against spore germination of some fungi, viz. Alternaria alternata, A. brassicae, Curvularia maculans, Curvularia sp., Colletotrichum gloeosporioides, Colletotrichum sp., Helminthosporium speciferum, H. pennisetti, Helminthosporium sp., and Ustilago cynodontis. The antifungal effect of single compounds was dose-dependent. If the mutual ratio of the two components in the mixture was changed from 1:1 to a major content of any of the two compounds, the inhibitory effect on spore germination decreased.
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