Effect of 2-chlorodeoxyadenosine therapy on bone marrow fibrosis in hairy cell leukemia
Language English Country Slovakia Media print
Document type Journal Article
PubMed
15004661
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Cladribine therapeutic use MeSH
- Middle Aged MeSH
- Humans MeSH
- Primary Myelofibrosis drug therapy MeSH
- Antineoplastic Agents therapeutic use MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Leukemia, Hairy Cell drug therapy pathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cladribine MeSH
- Antineoplastic Agents MeSH
The study shows the influence of 2-chlorodeoxyadenosine therapy on bone marrow fibrosis in patients with hairy cell leukemia. Eighteen patients were studied; bone marrow fibrosis was graded 0-4 according to the quantity and pattern of distribution of reticulin. The grade of bone marrow fibrosis was established before the therapy and then in 12- and 24-month intervals. Patients showed complete remission after the therapy and remarkable reduction of bone marrow fibrosis.
