The effects of intravenously administered methylxanthines on the proportion of goblet cells containing fucosylated glycoconjugates in rabbit tracheal epithelium
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15032328
DOI
10.1016/j.acthis.2003.10.002
PII: S0065-1281(03)00007-2
Knihovny.cz E-resources
- MeSH
- Alcian Blue chemistry MeSH
- Aminophylline pharmacology MeSH
- Bronchodilator Agents pharmacology MeSH
- Epithelial Cells chemistry drug effects metabolism MeSH
- Fucose metabolism MeSH
- Glycoconjugates analysis metabolism MeSH
- Histocytochemistry MeSH
- Injections, Intravenous MeSH
- Rabbits MeSH
- Lectins chemistry MeSH
- Cell Count MeSH
- Goblet Cells chemistry drug effects metabolism MeSH
- Secretory Vesicles chemistry drug effects metabolism MeSH
- Theophylline analogs & derivatives pharmacology MeSH
- Trachea chemistry cytology drug effects MeSH
- Ulex chemistry MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Alcian Blue MeSH
- Aminophylline MeSH
- Bronchodilator Agents MeSH
- etofylline MeSH Browser
- Fucose MeSH
- Glycoconjugates MeSH
- lectin, Aleuria aurantia MeSH Browser
- Lectins MeSH
- Theophylline MeSH
The proportion of goblet cells containing various fucosylated glycoconjugates was evaluated with the use of lectin histochemistry in rabbit tracheal epithelium at 15 and 30 min after intravenous administration of either aminophylline (Syntophyllin) or a mixture of etophylline and theophylline (Oxantil). Methylxanthine derivatives are nonspecific inhibitors of phosphodiesterases that are used to treat bronchial asthma; the proportion of fucosylated glycoconjugates strongly affects rheologic properties of respiratory tract mucus. It is concluded that administration of Syntophyllin dramatically lowered the proportion of goblet cells containing fucosylated glycoconjugates in rabbit tracheal epithelium, especially at 30 min after exposure. This decrease was strongest in the levels of alpha(1-2)-fucosylated glycoconjugates. Therefore, Syntophyllin substantially altered the composition and viscoelastic properties of mucus of the upper respiratory tract. The vasodilator Oxantil exerted less pronounced changes in the proportion of goblet cells, but the strongest effect was again found in the levels of alpha(1-2)-fucosylated glycoconjugates.
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