Fotodynamická terapie jako nová perspektivní metoda lécby nádorových onemocnení--II. Prehled fotosenzitizérů
[Photodynamic therapy as a new prospective method for cancer treatment--II. Overview of photosensitizers]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
15630992
- MeSH
- Photochemotherapy * MeSH
- Photosensitizing Agents chemistry therapeutic use MeSH
- Humans MeSH
- Neoplasms drug therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Photosensitizing Agents MeSH
Since the time when hematoporphyrine derivative (trade name Photofrin) has been introduced into clinical practice in Canada in 1993, a lot of new photosensitizers (PS) have been studied. Some of them successfully passed the clinical trials and are in use in the treatment of cancerous (ALA, temoporfin) and non-cancerous (verteporfin) diseases. The others (motexafin lutecium, talaporfin, phthalocyanines and SnET2) are entering or passing the clinical trials now. The newer PS are also called the second generation PS, when the first generation is composed of Photofrin only. The second generation PS usually possesses better properties, especially concerning absorption at longer wavelengths, shorter skin photosensitivity, better accumulation ratio between tumorous and healthy tissue and pharmacokinetics.
