Mocninná rovnice a kinetika liberace
[Power law equation and liberation kinetics]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't
PubMed
15751794
- MeSH
- Hypromellose Derivatives MeSH
- Diffusion MeSH
- Chemistry, Pharmaceutical MeSH
- Freeze Drying MeSH
- Methylcellulose analogs & derivatives MeSH
- Pilocarpine pharmacokinetics MeSH
- Tablets MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Hypromellose Derivatives MeSH
- Methylcellulose MeSH
- Pilocarpine MeSH
- Tablets MeSH
For the modelling of the kinetics of diffusion and relaxation in the polymer matrix, the power law equation in a two-parameter or three-parameter form is employed. The introductory part of the paper summarizes the employed varieties of the power law equation including the equation making it possible to distinguish diffusion from relaxation. The liberation kinetics of pilocarpinium chloride from lyophilized lamellae with graded amounts of hydroxypropylmethylcellulose is expressed by power law equations and their parameters are compared. The conclusion discusses the usability of the power law equation in the modelling of liberation of active ingredients and recommends the use of the three-parameter power law equation with a shift of the liberation out of the origin of the coordinates.
