Adhesion of erythrocytes to endothelial cells after acute exercise: differences in red blood cells from juvenile and adult rats
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16238460
DOI
10.33549/physiolres.930818
PII: 818
Knihovny.cz E-resources
- MeSH
- Cell Adhesion physiology MeSH
- Endothelial Cells cytology MeSH
- Erythrocyte Membrane metabolism MeSH
- Erythrocytes cytology metabolism MeSH
- Fibrinogen metabolism MeSH
- Fibronectins blood MeSH
- Rats MeSH
- Cells, Cultured MeSH
- N-Acetylneuraminic Acid metabolism MeSH
- Oxidation-Reduction MeSH
- Rats, Wistar MeSH
- Physical Exertion physiology MeSH
- Age Factors MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Fibrinogen MeSH
- Fibronectins MeSH
- N-Acetylneuraminic Acid MeSH
Erythrocytes (RBC) from untrained male Wistar rats and rat glomerular endothelial cells (EC) were used to investigate the effects of acute exercise (speed: 20 m/min, slope: 0, duration: 1 hour) on RBC membrane protein oxidation and adhesion to cultured EC. Experimental animals were divided into juvenile (age 10 weeks) and adult (age 30 weeks) groups for these studies. Immediately following exercise, juvenile rat RBC membrane protein oxidation was significantly enhanced. Adult rat RBC showed significantly higher basal protein oxidation than juvenile RBC; but the level of adult rat RBC membrane protein oxidation was unaffected by exercise. Prior to exercise, adult rat RBC showed significantly higher adhesion to EC than RBC of juvenile rat. There was no difference in plasma fibronectin or fibrinogen levels following exercise. Only juvenile rat RBC showed a significant decrease in sialic acid residue content following exercise. These experiments show that there are changes in RBC-EC interactions following exercise that are influenced by animal age.
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