Cytogenetic mapping of immunity-related genes in the domestic horse
Language English Country Great Britain, England Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
16293125
DOI
10.1111/j.1365-2052.2005.01348.x
PII: AGE1348
Knihovny.cz E-resources
- MeSH
- DNA Primers MeSH
- Species Specificity MeSH
- Genes genetics immunology MeSH
- In Situ Hybridization, Fluorescence MeSH
- Horses genetics immunology MeSH
- Humans MeSH
- Chromosome Mapping * MeSH
- Microsatellite Repeats genetics MeSH
- Synteny genetics MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- DNA Primers MeSH
Chromosomal locations of 19 horse immunity-related loci (CASP1, CD14, EIF5A, FCER1A, IFNG, IL12A, IL12B, IL12RB2, IL1A, IL23A, IL4, IL6, MMP7, MS4A2, MYD88, NOS2A, PTGS2, TFRC and TLR2) were determined by fluorescence in situ hybridization. For IFNG and PTGS2, this study is a confirmation of their previously reported position. In addition, microsatellite (HMBr1) was localized in the same region as IFNG. All genes were assigned to regions of conserved synteny and the data obtained in this study enhance the comparative human-horse map. Cytogenetic localization of IL6 to ECA4q14-q21.1 suggested a new breakage point that changes the order of loci compared with HSA7. The map assignments of these loci serve as anchors for other loci and will aid in the search for candidate genes associated with traits in the horse.
References provided by Crossref.org
Subchromosomal karyotype evolution in Equidae
