Alterations in plasma antioxidants during reperfusion of the ischemic small intestine in rats
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16297418
DOI
10.1016/j.rvsc.2005.09.010
PII: S0034-5288(05)00173-6
Knihovny.cz E-resources
- MeSH
- Antioxidants analysis MeSH
- Ischemia * MeSH
- Rats MeSH
- Uric Acid blood MeSH
- Oxidative Stress MeSH
- Lipid Peroxidation MeSH
- Peroxides metabolism MeSH
- Rats, Wistar MeSH
- Reactive Oxygen Species metabolism MeSH
- Reperfusion Injury physiopathology veterinary MeSH
- Serum Albumin MeSH
- Sulfhydryl Compounds blood MeSH
- Intestine, Small blood supply MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antioxidants MeSH
- Uric Acid MeSH
- perhydroxyl radical MeSH Browser
- Peroxides MeSH
- Reactive Oxygen Species MeSH
- Serum Albumin MeSH
- Sulfhydryl Compounds MeSH
The aim of this study was to evaluate the contribution of three plasma antioxidants (albumin, uric acid, SH groups) to the plasma total peroxyl radical-trapping antioxidant capacity (TRAP) in 2 and 4 h of intestinal reperfusion in rats. TRAP increased significantly both after 2 and 4 h of reperfusion. Neither albumin nor SH groups contributed significantly to this increase. TRAP was strongly influenced by the increase in uric acid concentration and also probably by the cell destruction caused by oxidative stress. Since the TRAP increase was accompanied by an increase in the level of thiobarbituric acid reactive substances (TBARS, a marker of lipid peroxidation), we can conclude that even such a large increase in TRAP is not sufficient to prevent the progression of lipid peroxidation and oxidative stress.
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