C1q complement component and -antibodies reflect SLE activity and kidney involvement
Language English Country Germany Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Adult MeSH
- Immunologic Factors metabolism MeSH
- Complement C1q immunology metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Lupus Nephritis blood complications immunology MeSH
- Predictive Value of Tests MeSH
- Antibodies blood MeSH
- Aged MeSH
- Antibody Specificity immunology MeSH
- Lupus Erythematosus, Systemic blood complications immunology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Immunologic Factors MeSH
- Complement C1q MeSH
- Antibodies MeSH
The role of the complement system in the pathogenesis of systemic diseases is very ambivalent. In systemic lupus erythematosus (SLE), many abnormalities in the activation of the complement system have been reported. The most important antibodies formed against the complement system in SLE are the ones associated with the C1q component. The aim of this study was to assess separately the anti-C1q antibodies and C1q component in the serum from 65 patients with SLE, then in individuals with (n=33) and without (n=32) lupus nephritis and with active (n=36) and nonactive (n=29) form of the disease (European Consensus Lupus Activity Measurement, ECLAM>3, ECLAM
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