In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16766478
DOI
10.1080/15287390500364283
PII: M36138H0038G3504
Knihovny.cz E-resources
- MeSH
- Acetylcholinesterase physiology MeSH
- Antidotes pharmacology MeSH
- Chemical Warfare Agents pharmacology MeSH
- Cholinesterase Inhibitors pharmacology MeSH
- Rats MeSH
- Brain drug effects MeSH
- Obidoxime Chloride pharmacology MeSH
- Organophosphates pharmacology MeSH
- Organothiophosphorus Compounds pharmacology MeSH
- Oximes pharmacology MeSH
- Rats, Wistar MeSH
- Pralidoxime Compounds pharmacology MeSH
- Pyridinium Compounds pharmacology MeSH
- Pyridines pharmacology MeSH
- Cholinesterase Reactivators pharmacology MeSH
- Trimedoxime pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Antidotes MeSH
- asoxime chloride MeSH Browser
- BI 6 MeSH Browser
- Chemical Warfare Agents MeSH
- Cholinesterase Inhibitors MeSH
- HLo 7 MeSH Browser
- Obidoxime Chloride MeSH
- Organophosphates MeSH
- Organothiophosphorus Compounds MeSH
- Oximes MeSH
- pralidoxime MeSH Browser
- Pralidoxime Compounds MeSH
- Pyridinium Compounds MeSH
- Pyridines MeSH
- Cholinesterase Reactivators MeSH
- tabun MeSH Browser
- Trimedoxime MeSH
- VX MeSH Browser
The efficacy of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate acetylcholinesterase inhibited by two nerve agents (tabun, VX agent) was tested in vitro. Both H oximes (HI-6, HLö-7) and the oxime BI-6 were found to be more efficacious reactivators of VX-inhibited acetylcholinesterase than pralidoxime and obidoxime. On the other hand, their potency to reactivate tabun-inhibited acetylcholinesterase was low and did not reach the reactivating efficacy of trimedoxime and obidoxime. Thus, none of these compounds can be considered to be a broad-spectrum reactivator of nerve agent-inhibited acetylcholinesterase in spite of high potency to reactivate acetylcholinesterase inhibited by some nerve agents. More than one oxime may be necessary for the antidotal treatment of nerve agent-exposed individuals.
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