Revision of the structure of escholidine
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16792417
DOI
10.1021/np060078e
Knihovny.cz E-resources
- MeSH
- Berberine Alkaloids chemistry MeSH
- Dioxoles chemistry MeSH
- Crystallography, X-Ray MeSH
- Molecular Conformation MeSH
- Molecular Structure MeSH
- Nuclear Magnetic Resonance, Biomolecular MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Berberine Alkaloids MeSH
- Dioxoles MeSH
- escholtzine MeSH Browser
The structure of the quaternary tetrahydroprotoberberine alkaloid escholidine is revised on the basis of 2D NMR spectroscopy and X-ray diffraction. In contrast to the originally reported constitution, escholidine bears an -OH group at C-9 and an -OCH3 group at C-10. The 1H and 13C NMR data and long-range 1H-13C and NOE interactions of escholidine are compared with those of thalifendine and tetrahydroberberrubine. The 15N NMR data of escholidine obtained by using long-range 1H-15N correlation experiments at natural abundance are also reported.
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