Expression of cellular prion protein on platelets from patients with gray platelet or Hermansky-Pudlak syndrome and the protein's association with alpha-granules
Language English Country Italy Media print
Document type Journal Article
PubMed
16885055
Knihovny.cz E-resources
- MeSH
- Creutzfeldt-Jakob Syndrome blood transmission MeSH
- Cytoplasmic Granules chemistry ultrastructure MeSH
- Hermanski-Pudlak Syndrome blood MeSH
- Humans MeSH
- Transfusion Reaction * MeSH
- Prions blood MeSH
- PrPC Proteins blood MeSH
- Blood Platelets chemistry MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Prions MeSH
- PrPC Proteins MeSH
The cellular prion protein (PrPc) is a membrane glycoprotein expressed on many human cells including platelets. We investigated the cellular localization of platelet PrPc. In resting platelets most PrPc was localized inside the cells. The correlation of PrPc and P-selectin surface up-regulation after platelet activation suggested its association with alpha-granules. This was confirmed by normal expression of PrPc on Hermansky-Pudlak syndrome platelets, which lack dense granules, and failure of gray platelet syndrome platelets, which lack alpha-granules, to up-regulate PrPc. Our results warrant further studies on the role of platelet PrPc in the transmission of prion diseases by blood transfusion.
