Effect of perinatal hypoxia on cardiac tolerance to acute ischaemia in adult male and female rats
Jazyk angličtina Země Austrálie Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
16895545
DOI
10.1111/j.1440-1681.2006.04423.x
PII: CEP4423
Knihovny.cz E-zdroje
- MeSH
- hypoxie plodu patologie patofyziologie MeSH
- infarkt myokardu patologie patofyziologie MeSH
- koronární cévy chirurgie MeSH
- krysa rodu Rattus MeSH
- modely nemocí na zvířatech MeSH
- myokard patologie MeSH
- potkani Wistar MeSH
- reperfuzní poškození myokardu patologie patofyziologie prevence a kontrola MeSH
- sexuální faktory MeSH
- srdce patofyziologie MeSH
- srdeční arytmie patologie patofyziologie prevence a kontrola MeSH
- srdeční frekvence MeSH
- srdeční komory MeSH
- těhotenství MeSH
- tělesná hmotnost MeSH
- velikost orgánu MeSH
- zpožděný efekt prenatální expozice MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
1. The number of adult patients undergoing surgery for congenital cyanotic defects in childhood has increased significantly. Therefore, the aim of the present study was to examine the effect of perinatal hypoxia on the tolerance of the adult myocardium to acute ischaemia-reperfusion injury. 2. Pregnant Wistar rats were exposed to intermittent hypobaric hypoxia 7 days before delivery; pups were born under normoxic conditions and exposed to hypoxia again for 10 postnatal days. After the last hypoxic exposure, all animals were kept for an additional 3 months under normoxic conditions. All experiments were performed on 90-day-old rats. 3. Ventricular arrhythmias were assessed on isolated perfused hearts during 30 min occlusion of the left anterior descending coronary artery. Infarct size was measured on isolated hearts (40 min regional ischaemia and 120 min reperfusion) and on open-chest animals (20 min regional ischaemia and 3 h reperfusion). 4. Perinatal exposure to hypoxia significantly increased cardiac tolerance to ischaemic injury in adult females, as evidenced by the lower incidence and severity of ischaemic ventricular arrhythmias, compared with the normoxic group. The effect of perinatal hypoxia on ischaemic arrhythmias in males was quite the opposite. Myocardial infarct size measured in open-chest animals only was significantly smaller in normoxic females compared with normoxic males. Perinatal exposure to hypoxia had no effect on infarct size in either setting or sex. 5. The results of the present study support the hypothesis that perinatal hypoxia is a primary programming stimulus in the heart that may lead to sex-dependent changes in cardiac tolerance to acute ischaemia in later adult life. This would have important implications for patients who have experienced prolonged hypoxaemia in early life.
Citace poskytuje Crossref.org
Sex Differences in Cardiac Tolerance to Oxygen Deprivation - 40 Years of Cardiovascular Research
Sixty Years of Heart Research in the Institute of Physiology of the Czech Academy of Sciences
Sex-based differences in cardiac ischaemic injury and protection: therapeutic implications
